If you know you're going to pickup something huge, take it off, set it in the garage, easy peasy. Removal is easy, genuinely takes less than 10 minutes. So I wouldn't put the Mona Lisa in my bed and drive through a rainstorm, but if your stuff is in a suitcase, or even closed boxes you'll be OK.

This cover is NOT waterproof (I did not install the tailgate seal and have open back stake pockets). Not that it rains a ton in Phoenix, but if heading up North in AZ you can run into weather. I drive a lot of highway miles, a lot at speeds I'd rather not put in writing (they always seemed reasonable and prudent to me). There are some reviews on here that talk about vibration on the highway. That's the benefit of this cover - lots of easy options! Sometimes I'm running with tonneau closed, sometimes with tonneau open, sometimes with tonneau removed. My most recent haul was 1,600 lbs of cinder block debris from a demo project. In the time I've owned this I moved houses taking truck loads of stuff to the new house while it was being renovated.

I use my bed for everything from the typical Home Depot run with lumber or pipes, hauling random big things I've bought, miscellaneous home projects, etc. If it broke tomorrow, I'd go buy the same one.

Rambox truck